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When attempting to run a GRT backup of the Information Store to tape for Exchange 2007 running on a Windows 2008 server  the job fails with the above error.

The same job when targeted to backup to disk completes successfully but when trying to run a GRT restore from the successful backup set the job fails with the following error:
Unable to attach to a resource.  Make sure that all selected resources exist and are online, and then try again


To resolve the issue, perform one of the following procedures on the Client Access server. The procedure to implement the workaround depends on whether the Exchange topology is running the Client Access server role and Mailbox server role on the same Exchange server or on different Exchange servers.

For a single-server topology where the Client Access server role is running on the same Exchange server as the Mailbox server role.
1. Open the hosts file located at %SystemRoot%\system32\drivers\etc\ by using an editor such as Notepad.
%SystemRoot% refers to the drive where the Windows system files are located.
2.  Comment out the line that references the IPv6 address.
# :::1    localhost

3. Add the following lines into the file:
127.0.0.1                   hostname of the computer
127.0.0.1                   FQDN of the computer
actual IPv4 address    hostname of the computer
actual IPv4 address    FQDN of the computer

3. Save the changes made to the file and restart the Backup Exec services on the Exchange server.
4. Run an Information Store backup/restore and verify the results.

NOTE: If backup fails even after following above steps,disable IPv6 completely if there is no other application using it.

For a multiple-server topology where the Client Access server role is not running on the same Exchange server as the Mailbox server role

The following changes need to be made on the Client Access server in the multiple server topology:
1. Under Network Connections, select the network adapter, and then click Properties.
2. In the properties window, uncheck the check box for Internet Protocol Version 6 (IPv6).
Note: 
Clearing this check box causes the RPCProxy component on the Client Access server to use TCP/IPv4 to talk to the DSProxy component on the Mailbox server. 
3. Click on the Start menu, and then click Run. Type regedit in the Open box.
4. Using Registry Editor, locate the following registry key:
HKEY_Local_Machine\SYSTEM\CurrentControlSet\Services\Tcpip6\Parameters
Warning: Incorrect use of the Windows registry editor may prevent the operating system from functioning properly. Great care should be taken when making changes to a Windows registry. Registry modifications should only be carried-out by persons experienced in the use of the registry editor application. It is recommended that a complete backup of the registry and workstation be made prior to making any registry changes.
5. Right-click the Parameters key, click New, and then click DWORD (32-bit) Value. For the key, add the following values:
Name: DisabledComponents
Data: 0xffffffff
6. Restart the Client Access server.
7. Run an Information Store backup/restore and verify the results.


The above error message may continue to occur even after having made the changes mentioned above if :
A.) Exchange 2007  is installed on a Windows 2008 machine
AND
B) In the resource order for the backup selection list Information Store is not the first resource to be backed up
AND
C) Backup job is targeted to tape device

Resolution:

To resolve the issue edit the backup selection list such that the Microsoft Information Store is the first resource to be backed up followed by the other local resources on the server.